Possible side effects include...

This is pretty funny. Not, of course, for the poor folks who had their frontal lobes poked into mush. Found on mentalfloss.com -

Worst Nobel Prize Winner Ever: Once a Nobel Prize is given, it cannot be revoked. Now and again, the award goes to someone who maybe did not deserve it, but the most undeserving winner has to be Antonio Egas Moniz, the Portuguese physician who won the prize for medicine in 1946 for inventing—yes—the leucotomy prefrontal (lobotomy). Egas Moniz’s surgery consisted of—if we may simplify it a bit—drilling a few holes in a patient’s skull and then repeatedly stabbing the patient in the brain. The lobotomy seemed to be successful at curing people of schizophrenic and paranoid psychoses, but they proved to have fairly serious side effects,such as “becoming a vegetable” and “becoming dead.” Although lobotomies are rare today, thanks to an improved understanding of mental illness and psychosis treatments, they’re still occasionally performed in some parts of the world.